Effect of exogenous Melatonin administration on Spermatogenesis in chronic unpredictable stress rat model-Reference-Cited by-同舟云学术

Effect of exogenous Melatonin administration on Spermatogenesis in chronic unpredictable stress rat model

Published:2023-08-20 Issue:2 Volume:XXXIII Page:1-9
ISSN:2521-9715
Container-title:Revista Científica de la Facultad de Ciencias Veterinarias
language:es
Short-container-title:RC FCV-LUZ

Author:

Gökçek İshak¹^ORCID,Aydın Leyla²^ORCID,Cellat Mustafa¹^ORCID,Yavaş İlker³^ORCID,Kutlu Tuncer⁴^ORCID

Affiliation:

1. Hatay Mustafa Kemal University, Faculty of Veterinary Science, Department of Physiology. Hatay, Turkey

2. Ankara Yıldırım Beyazıt University, Faculty of Medicine, Department of Physiology. Ankara, Turkey

3. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination. Hatay, Turkey

4. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Pathology. Hatay, Turkey

Abstract

This study investigated the hormonal, inflammatory, oxidant–antioxidant, and histopathological effects of exogenous Melatonin administration on Spermatogenesis in rats' chronic unpredictable stress model (CUSM). In the study, stress caused a decrease in follicle stimulating–hormone (FSH), luteinizing hormone (LH), Testosterone, Melatonin, Glutathione (GSH), Glutathione peroxidase (GSH–Px), catalase, interleukin 10 (IL–10) levels and motility, and an increase in Corticosterone, nuclear factor kappa beta (NF–kB), tumor necrosis factor–alpha (TNF–α), interleukin 1 beta (IL–1β), interleukin 6 (IL–6), abnormal sperm, dead/live sperm ratio and exogenous Melatonin reduced inflammatory cytokines and oxidative stress and improved spermatological parameters (P<0.05). Melatonin also partially corrected stress–induced changes in testicular morphology. As a result, using Melatonin in rats with CUSM may be effective in improving spermatological parameters through anti–inflammatory and antioxidant mechanisms.

Publisher

Universidad del Zulia

Subject

General Veterinary

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