Methods to monitor the therapy oral anticoagulants: the current problems.

Author:

Antovic J.1,Kondratieva Tat'yana B.2

Affiliation:

1. Karolinska Institutet; Karolinska University Hospital

2. I.M. Sechenov First Moscow State Medical University, (Sechenov University)

Abstract

Oral anticoagulants antivitamin-K (ОАС - AVК) are highly effective drugs that prevent the development of venous thrombosis, stroke in atrial fibrillation. Routine monitoring is not recommended for DOAC. If measurements are necessary LC-MS/MS is the gold standard. The classical coagulation assays, PT-INR and aPTT, have no or very limited utility. The absence of the ability of simple laboratory tests in emergent or urgent surgery or procedures still remains unresolved.

Publisher

Medical Informational Agency Publishers

Subject

General Medicine

Reference15 articles.

1. Poller L., Roberts C., Ibrahim S., Keown M., Ageno W., van den Besselaar A.M.H.P. et al. Screening computer-assisted dosage programs for anticoagulation with warfarin and other vitamin K-antagonists: minimum safety requirements for individual programs. J. Thromb. Haemost. 2009; 7(10): 1736.

2. Njaastad A.M., Abildgaard U., Lassen J.F. Gains and losses of warfarin therapy as

3. performed in an anticoagulation clinic. J. Intern. Med. 2006; 259(3): 296-304.

4. Roehrig S., Straub A., Pohlmann J., Lampe T., Pernerstorfer J., Schlemmer K.H. et al. Discovery of the novel antithrombotic agent 5-Chloro-N-(?Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B. et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J. 2016; 37(38): 2893-962.

5. Lippi G., Favaloro E.J. Recent guidelines and recommendations for laboratory assessment of the direct oral anticoagulants (DOACs): is there consensus? Clin. Chem. Lab. Med. 2015; 53(2): 185-97.

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3