Affiliation:
1. N.N. Burdenko Voronezh State Medical University
Abstract
The article is a review of the literature, which presents the results of experimental and clinical studies, meta-analysis data on the effects of hypothyroidism on the clinical course of heart failure, the association between hypothyroidism and clinical outcomes in patients with heart failure. Thyroid gland dysfunction is a risk factor for development of cardiovascular diseases. From all types of thyroid gland dysfunction hypothyroidism is the most common. Increasing of thyroid-stimulating hormone level (which happens in patients with hypothyroidism) can influence the clinical course of chronic heart failure because of its extrathyroid effects - namely - influence on lipide metabolism, endothelial function of vessels and blood pressure. Apart from adverse effects of hormonal deficiency of thyroid gland on the start and progression of a chronic heart failure, the heart failure itself can make negative impact on a thyroid gland functioning, therefore pathophysiological "vicious circle" is formed. Manifest hypothyroidism is associated with an increased risk of general and cardiovascular mortality and frequency of hospitalizations of patients with a heart failure. Association between subclinical hypothyroidism (SCH) and heart failure is less studied. Figuring out the mechanisms of influence of thyroid gland hypofunction on systolic and diastolic function of myocardium may be important for effective treatment of heart failure and improvement of clinical outcomes.
Publisher
Medical Informational Agency Publishers
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