Features of erosive­ulcerative lesions of stomach and duodenum in patients with migraine

Abstract

A number of epidemiological studies have shown the Association of migraine with peptic ulcer disease (JB), however, the processes underlying the pathogenesis and features of the course of these diseases have not been fully studied. Material and methods. A comprehensive examination of the gastrointestinal tract was performed in 114 patients with migraine. Focused on the major clinical and psychological characteristics of patients depending on the availability of gastroduodenopathies, especially pain therapy and serotonin levels in the blood serum. Results. In 18.4% of patients with migraine, regardless of its type, erosive and ulcerative lesions of the stomach and duodenum were detected. In patients with chronic migraine, gastric ULCER developed more often (PF =0.022), the clinical features of the combination of migraine and ULCER were more pronounced intensity of abdominal pain and heartburn. High (5 or more times a week) frequency of nonsteroidal anti-inflammatory drugs (NSAIDs) was an important ulcerogenic factor in patients with migraine. Serotoninergic hypofunction can be discussed as a mechanism that determines the comorbid relationship of migraine and JB. The combination of migraine with NSA contributed to the formation of a more severe course of migraine. In assessing the quality of life indicators of all scales in such patients were lower . Gastropathy can be considered as an additional factor of migraine chronization, requiring appropriate therapeutic interventions to improve the quality of life of patients.