Melatonin: the possibility to analyze the marker of age-related pathology in buccal epithelium and urine-Reference-Cited by-同舟云学术

Melatonin: the possibility to analyze the marker of age-related pathology in buccal epithelium and urine

Published:2017-04-21 Issue:2 Volume:95 Page:136-139
ISSN:2412-1339
Container-title:Clinical Medicine (Russian Journal)
language:
Short-container-title:Klin. med.

Author:

Konovalov S. S.¹,Polyakova V. O.²,Drobintseva A. O.³,Kvetnoy I. M.²,Kvetnaya T. V.⁴,Lin’kova Natalya S.⁵

Affiliation:

1. International Academy of Ecology, Human Safety and Nature Science

2. D.O. Ott Research Institute of Obstetrics and Gynecology; Saint Petersburg Institute of Bioregulation and Gerontology

3. D.O. Ott Research Institute of Obstetrics and Gynecology

4. Saint Petersburg Institute of Bioregulation and Gerontology

5. Saint Petersburg Institute of Bioregulation and Gerontology; Peter the Great Saint-Petersburg Polytechnical University

Abstract

Extrapineal and pineal melatonin is the marker of the aging rate of organism making it possible to characterize functional condition of the neuro-immuno-endocrine system. In this article we have used the new method for non-invasive diagnostics of melatonin expression in buccal epithelium and determination of the main melatonin metabolite 6-hydroxymelatonin sulfate (6-HMS) in urine of elderly people. Normal, impaired and enhanced melatonin expression was documented in 20.5%, 43.2% and 36.30% of the patients respectively. Such comprehensive melatonin and 6-COMT studies can be recommended for elderly patients with oncological, neurodegenerative, cardiovascular diseases, and ageing macular dystrophy. Moreover, melatonin expression analysis in buccal cells can be used for integral investigation of biorhythms in elderly people.

Publisher

Medical Informational Agency Publishers

Subject

General Medicine

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