Effects of substrate conformational strain on binding kinetics of catalytic antibodies
Author:
Affiliation:
1. Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
2. Graduate School of Science, Osaka Prefecture University
Publisher
Biophysical Society of Japan
Subject
General Medicine
Link
https://www.jstage.jst.go.jp/article/biophysico/13/0/13_135/_pdf
Reference9 articles.
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2. [5] Fujii, I., Tanaka, F., Miyashita, H., Tanimura, R. & Kinoshita, K. Correlation between antigen-combining-site structures and functions within a panel of catalytic antibodies generated against a single transition state analog. J. Am. Chem. Soc. 117, 6199–6209 (1995).
3. [6] Gigant, B., Tsumuraya, T., Fujii, I. & Knossow, M. Diverse structural solutions to catalysis in a family of antibodies. Structure 7, 1385–1393 (1999).
4. [8] Miyashita, H., Karaki, Y., Kikuchi, M. & Fujii, I. Prodrug activation via catalytic antibodies. Proc. Natl. Acad. Sci. USA 90, 5337–5340 (1993).
5. [9] Oda, M. & Azuma, T. Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens. Mol. Immunol. 37, 1111–1122 (2000).
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