Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats-Reference-Cited by-同舟云学术

Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats

Published:2024-05-31 Issue:1 Volume:11 Page:47-55
ISSN:2458-7575
Container-title:Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi
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Author:

Ayazoglu Demir Elif¹^ORCID,Mentese Ahmet¹^ORCID,Livaoglu Ayten²^ORCID,Türkmen Nihal³^ORCID,Demir Selim⁴^ORCID,Aliyazıcıoğlu Yüksel¹^ORCID

Affiliation:

1. KARADENİZ TEKNİK ÜNİVERSİTESİ

2. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, TRABZON KANUNİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ

3. RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ

4. Karadeniz Teknik Üniversitesi Sağlık Bilimleri Fakültesi Beslenme ve Diyetetik Bölümü

Abstract

Although astaxanthin (ASX) is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date. It was therefore aimed to investigate whether ASX is therapeutic against 5-FU-induced ovotoxicity in this study. Rats were first exposed to 5-FU (100 mg/kg) and then treated ASX (250 μg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by 5-FU administration (p<0.05). Treatment with ASX significantly alleviated these markers (p<0.05). These findings reveal that ASX may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.

Publisher

Bilecik Seyh Edebali Universitesi Fen Bilimleri Dergisi

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