Association of formation of urinary calculi with blood lipid levels.

Abstract

We aimed to analyze the composition of urinary calculi and its correlations with blood lipids such as triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL -C), and high-density lipoprotein cho-lesterol (HDL -C). Three hundred patients with urinary calculi treated from January 2020 to July 2021 were selected retrospectively into a urinary calculi group, while three hundred healthy individuals who received physical examina-tion in our hospital during the same period were enrolled in a control group. Us-ing the Spearman correlation analysis, we investigated the correlation between the composition of urinary calculi and dyslipidemia and explored the factors affecting urinary calculi through multivariate logistic regression analysis.The serum levels of TG and TC were significantly higher (p<0.05), the serum HDL -C level was significantly lower (p<0.05), while the serum LDL -C level displayed no significant difference (p>0.05) in the urinary calculi group compared with those in the control group. The proportion of uric acid calculi was significantly higher in urinary calculi patients with dyslipidemia than that in those with normal blood lipids (p<0.05). However, no significant difference was observed in the proportions of infectious calculi and calcium calculi between urinary calculi patients with dyslipidemia and those with normal blood lipids (p>0.05). Dyslipidemia was positively correlated with uric acid calculi (p<0.05) but not associated with infectious calculi or calcium calculi (p>0.05). TG was a risk factor for urinary calculi (p<0.05). The formation of urinary calculi is closely associated with blood lipid levels. Dyslipidemia, especially hypertriglyceride-mia, can easily induce the formation of uric acid calculi.