Abstract
Medicinal plants have always obtained a high interest in the management of diseases and conditions. In this regard, Plantago major is a perennial plant, and is native to most of Europe, Northern, and Central Asia. Plantago is a genus widely distributed all over the world; P. major is spread in temperate regions of Asia, South Australia, North America, and North Africa and the leaves of P. major have been used for centuries to treat diseases relating to skin, digestive organs and blood circulation like wounds, inflammation, and hypertension. Greek physicians described the traditional use of P. major in wound healing already in the first century A.D. P. major contains biologically active compounds, such as polysaccharides, lipids, caffeic acid derivatives, flavonoids, iridoid glycosides, alkaloids, and terpenoids, and also the presence of different vitamins, such as ascorbic acid and carotenoids. In this paper, pharmacological properties, adverse events, toxicity, and applications of Plantago major are evaluated, and beneficial approaches might be provided for future clinical trials, and new pharmaceutical compounds of plantain are made.