Affiliation:
1. Tishreen University Hospital, Faculty of Medicine, Lattakia, Syria
2. Tishreen University, Lattakia, Syria
Abstract
Allergic diseases in children have increased significantly. In recent years, it affects up to 35% of children. The current study aimed to investigate the value of the umbilical cord blood total IgE levels in the prediction of the development of allergic diseases during 8 years of follow-up. Methods — In cross-sectional study included 500 infants who were born in the obstetrics department at Tishreen and Al-Assad University Hospitals during the period 2007-2015. Questionnaires were administered after the birth included gender, gestational age, birth weight, mode and season of delivery, smoking during pregnancy, and family history of allergic diseases. Umbilical cord blood total IgE levels were measured. The infants were followed up for eight years for subsequent development of allergic disorders. Results — 214 (42.8%) of 500 newborns had high umbilical cord blood total IgE levels. We followed 143 of 214 newborns for 8 years; there was an allergic family history in 51.7% of newborns. During the following period, allergic diseases developed in 76.22% of the children with high umbilical cord blood total IgE levels. Allergic symptoms in children varied between nasal allergy (19.6%), skin allergy (eczema and urticarial) (25.2%), childhood asthma (31.5%). The rate of allergic symptoms development in the presence of two factors (family history and high umbilical cord blood total IgE) was 51.7%. Conclusion — We found a high prevalence of allergic diseases in children with high umbilical cord blood total IgE. The current study could be used as a preventative strategy to reduce the risk of allergic diseases by predictive of subsequent.
Publisher
LLC Science and Innovations
Reference18 articles.
1. Baççıoğlu A, Söğüt A, Kılıç Ö, Beyhun E. The Prevalence of Allergic Diseases and Associated Risk Factors in School-Age Children and Adults in Erzurum, Turkey. Turk Thorac J 2015; 16(2): 68-72. https://doi.org/10.5152/ttd.2015.4229.
2. Campbell DE, Boyle RJ, Thornton CA, Prescott SL. Mechanisms of allergic disease-environmental and genetic determinants for the development of allergy. Clinical and experimental allergy. Clin Exp Allergy 2015; 45(5): 844-858. https://doi.org/10.1111/cea.12531.
3. Brown MA, Halonen MJ, Martinez FD. Cutting the cord: is birth already too late for primary prevention of allergy? Clin Exp Allergy 1997; 27(1): 4-6. https://pubmed.ncbi.nlm.nih.gov/9117879.
4. Nabavi M, Ghorbani R, Asadi AM, Faranoush M. Factors associated with cord blood IgE levels. Asian Pac J Allergy Immunol 2013; 31(2): 157-162. https://doi.org/10.12932/ap0234.31.2.2013.
5. Kjellman NI, Croner S. Cord blood IgE determination for allergy prediction -- a follow-up to seven years of age in 1,651 children. Ann Allergy 1984; 53(2): 167-171. https://pubmed.ncbi.nlm.nih.gov/6465625.