1. From the Division of Respiratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (S.L.C., F.C., E.J.P., I.N.); Faculty of Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (G.M., R.L.H.); and Faculty of Medicine, Department of Physiology, University of Toronto, Toronto, Ontario, Canada (R.L.H.).