1. From the Department of Anesthesiology, Surgical Services and Intensive Care, Karolinska University Hospital, Stockholm, Sweden (Å.L., E.C., J.U., L.I.E., M.J.F.); Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology (Å.L., A.E., A.H.C., S.M., E.C., J.U., L.I.E., M.J.F.) and Medical Statistics Unit, Department of Learning, Informatics, Managements and E