1. From the Department of Anesthesia, University of Toronto, and The Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Ontario, Canada (N.M.G.); Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada, and The Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York (B.E.S.); Interdepartmental Division of Crit