Affiliation:
1. Pediatric Gastroenterology Service, Hospital Civil de Guadalajara “Dr. Juan I. Menchaca” Salvador Quevedo y Zubieta, Guadalajara, Jalisco, México
2. Universidad de Guadalajara, University Center for Health Sciences
3. Pediatric Infectology Service, Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”
4. Universidad de Guadalajara, Tonalá University Center.
Abstract
We describe the survival of children with acute liver failure (ALF), chronic liver disease (CLD), or acute-on-chronic liver failure (ACLF) with poor access to liver transplantation (LT). A retrospective cohort study of 42 patients <18 years of age was conducted in the Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”. The median age was 76 months; 57.1% were female, 40.5% presented with ALF, 35.7% with CLD, and 23.8% with ACLF. Also, 38.1% (16/42) presented liver disease of unknown etiology. Death occurred in 45.2%; 14.3% were transferred to another hospital, and none received LT. Mortality in ALF, CLD, and ACLF was 76%, 0%, and 60%, respectively. In the survival analysis, within the first 20 months after diagnosis, the mortality rate was greater than 50% with ALF. The importance of having referral programs that perform liver transplantation is highlighted by the poor prognosis of the patients, despite conservative treatment.
Subject
General Earth and Planetary Sciences,General Environmental Science