The local and systemic effects of immune function on fracture healing-Reference-Cited by-同舟云学术

The local and systemic effects of immune function on fracture healing

Published:2024-03 Issue:2S Volume:7 Page:
ISSN:2574-2167
Container-title:OTA International
language:en
Short-container-title:

Author:

Evans Andrew R.¹,Giannoudis Peter V.²,Leucht Philip³,McKinley Todd O.⁴,Gaski Greg E.⁵,Frey Katherine P.⁶,Wenke Joseph C.⁷,Lee Christopher⁸

Affiliation:

1. Warren Alpert School of Medicine at Brown University, University Orthopedics, Inc, Providence, RI

2. Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Clarendon Wing, Level D, Leeds, West Yorkshire, United Kingdom

3. NYU Langone Orthopedic Hospital, New York, NY

4. University of Indiana, Indianapolis, IN

5. University of Virginia School of Medicine, Inova Fairfax Medical Campus, Falls Church, VA

6. Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

7. UTMB Department of Orthopaedic Surgery and Rehabilitation, Shriners Children's Texas, Galveston, TX

8. UCLA, Los Angeles, CA

Abstract

Abstract The immune system plays an integral role in the regulation of cellular processes responsible for fracture healing. Local and systemic influences on fracture healing correlate in many ways with fracture-related outcomes, including soft tissue healing quality and fracture union rates. Impaired soft tissue healing, restricted perfusion of a fracture site, and infection also in turn affect the immune response to fracture injury. Modern techniques used to investigate the relationship between immune system function and fracture healing include precision medicine, using vast quantities of data to interpret broad patterns of inflammatory response. Early data from the PRECISE trial have demonstrated distinct patterns of inflammatory response in polytrauma patients, which thereby directly and indirectly regulate the fracture healing response. The clearly demonstrated linkage between immune function and fracture healing suggests that modulation of immune function has significant potential as a therapeutic target that can be used to enhance fracture healing.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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