Combining Treg Therapy With Donor Bone Marrow Transplantation: Experimental Progress and Clinical Perspective

Author:

Weijler Anna Marianne1,Wekerle Thomas1

Affiliation:

1. Division of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.

Abstract

Donor-specific tolerance remains a goal in transplantation because it could improve graft survival and reduce morbidity. Cotransplantation of donor hematopoietic cells to achieve chimerism is a promising approach for tolerance induction, which was successfully tested in clinical trials. However, current protocols are associated with side effects related to the myelosuppressive recipient conditioning, which makes it difficult to introduce them as standard therapy. More recently, adoptive cell therapy with polyclonal or donor-specific regulatory T cells (Treg) proved safe and feasible in several transplant trials, but it is unclear whether it can induce tolerance on its own. The combination of both approaches—Treg therapy and hematopoietic cell transplantation—leads to chimerism and tolerance without myelosuppressive treatment in murine models. Treg therapy promotes engraftment of allogeneic hematopoietic cells, reducing conditioning requirements and enhancing regulatory mechanisms maintaining tolerance. This review discusses possible modes of action of transferred Treg in experimental chimerism models and describes translational efforts investigating the potent synergy of Treg and chimerism.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Transplantation

Reference106 articles.

1. Strategies for long-term preservation of kidney graft function.;Wekerle;Lancet,2017

2. Exploring the complexity of death-censored kidney allograft failure.;Mayrdorfer;J Am Soc Nephrol,2021

3. The Nobel lectures in immunology. The Nobel Prize for physiology or medicine, 1960. Immunological tolerance.;Medawar;Scand J Immunol,1991

4. Tolerance versus immunosuppression: a perspective.;Halloran;Am J Transplant,2008

5. Tolerance—is it worth it?;Finger;Cold Spring Harb Perspect Med,2014

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