Affiliation:
1. From the Department of Anesthesiology, Downstate Medical Center, State University of New York, Brooklyn, New York.
Abstract
Abstract
Intracranial and Hemodynamic Changes after Succinylcholine Administration in Cats. By Cottrell JE, Hartung J, Giffin JP, and Shwiry B. Anesthesia & Analgesia 1983; 62:1006–9. Reprinted with permission.
Bolus injections of succinylcholine (1.5 mg/kg) significantly increased intracranial pressure (ICP) in cats under normal conditions from control levels of 8 +/- 1 mmHg to 16 +/- 3 mmHg (+/- SEM, P less than 0.01), and in the presence of artificially increased ICP from control levels of 27 +/- 1 mmHg to 47 +/- 4 mmHg (P less than 0.01). These approximately 100% increases in ICP were accompanied by a transitory decrease in mean arterial pressure (approximately 10 s), followed by a 15 to 20% increase (P less than 0.05). Pulmonary arterial pressure increased 20 to 30% (P less than 0.05). These results, when considered in conjunction with results previously obtained in humans, suggest that succinylcholine may be contraindicated in neurosurgical patients.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Anesthesiology and Pain Medicine
Reference33 articles.
1. Preoperative intermittent positive pressure breathing therapy in patients with chronic obstructive lung disease: Effect on postoperative pulmonary complications.;Anesth Analg,1973
2. Changes in airway resistance following droperidol, hydroxyzine, and diazepam in normal volunteers.;Anesth Analg,1976
3. Furosemide- and mannitol-induced changes in intracranial pressure and serum osmolality and electrolytes.;Anesthesiology,1977
4. Furosemide and human head injury.;J Trauma,1981
5. Intracranial pressure changes induced by sodium nitroprusside in patients with intracranial mass lesions.;J Neurosurg,1978
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献