Author:
Nwanaji-Enwerem Jamaji C.,Cardenas Andres,Goodrich Jaclyn M.,Furlong Melissa A.,Jung Alesia M.,Collender Philip A.,Caban-Martinez Alberto J.,Grant Casey,Beitel Shawn C.,Littau Sally,Urwin Derek J.,Gabriel Jamie J.,Hughes Jeff,Gulotta John,Wallentine Darin,Burgess Jefferey L.
Abstract
Objective
The aim of the study is to examine associations between years of firefighting service and eight chronological age-adjusted measures of blood leukocyte epigenetic age acceleration: Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, and DNAm telomere length.
Methods
The study used a repeated measures analysis of data from 379 incumbent firefighters from eight career departments and 100 recruit firefighters from two of the departments, across the United States.
Results
Incumbent firefighters had on average greater epigenetic age acceleration compared with recruit firefighters, potentially due to the cumulative effect of occupational exposures. However, among incumbent firefighters, additional years of service were associated with epigenetic age deceleration, particularly for GrimAge, a strong predictor of mortality.
Conclusions
Long-term studies with more specific occupational exposure classification are needed to better understand the relationship between years of service and aging biomarkers.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Public Health, Environmental and Occupational Health
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献