Stratification of Stage II Colon Cancer Using Recurrence Prediction Value-Reference-Cited by-同舟云学术

Stratification of Stage II Colon Cancer Using Recurrence Prediction Value

Published:2023-10-12 Issue: Volume: Page:
ISSN:0003-4932
Container-title:Annals of Surgery
language:en
Short-container-title:

Author:

Mizuno Shodai¹,Shigeta Kohei¹,Kato Yujin¹,Okui Jun¹²,Morita Satoru¹,Sonal Swati³,Goldstone Robert³,Berger David³,Al-Masri Rama⁴,Al-Masri Mahmoud⁴,Tajima Yuki⁵,Kikuchi Hiroto⁵,Hirata Akira⁵,Nakadai Jumpei⁶,Baba Hideo⁶,Sugiura Kiyoaki⁷,Hoshino Go⁷,Seo Yuki⁷,Makino Akitsugu⁸,Suzumura Hirofumi⁸,Suzuki Yoshiyuki⁹,Adachi Yoko⁹,Shimada Takehiro⁹,Kondo Takayuki¹⁰,Matsui Shimpei¹,Seishima Ryo¹,Okabayashi Koji¹,Kitagawa Yuko¹,Kunitake Hiroko³

Affiliation:

1. Department of Surgery, Keio University School of Medicine, Tokyo, Japan

2. Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan

3. General and Gastrointestinal Surgery, Massachusetts General Hospital, MA, USA

4. Department of Surgery, King Hussein Cancer Center, Amman, Jordan

5. Department of Surgery, Hiratsuka City Hospital, Kanagawa, Japan

6. Department of Surgery, Saitama City Hospital, Saitama, Japan

7. Department of Surgery, Japan Red Cross Ashikaga Hospital, Tochigi, Japan

8. Department of Surgery, Saiseikai Utsunomiya Hospital, Tochigi, Japan

9. Department of Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan

10. Department of Surgery, Kawasaki Municipal Hospital, Kanagawa, Japan

Abstract

Objective: To create a recurrence prediction value (RPV) of high-risk factor and identify the patients with high risk of cancer recurrence. Summary Background Data: There are several high-risk factors known to lead to poor outcomes. Weighting each high-risk factor based on their association with increased risk of cancer recurrence can provide a more precise understanding of risk of recurrence. Methods: We performed a multi-institutional international retrospective analysis of patients with Stage II colon cancer patients who underwent surgery from 2010 to 2020. Patient data from a multi-institutional database were used as the Training data, and data from a completely separate international database from two countries were used as the Validation data. The primary endpoint was recurrence-free survival (RFS). Results: A total of 739 patients were included from Training data. To validate the feasibility of RPV, 467 patients were included from Validation data. Training data patients were divided into RPV low (n = 564) and RPV high (n = 175). Multivariate analysis revealed that risk of recurrence was significantly higher in the RPV high than the RPV low (Hazard ratio (HR) 2.628; 95% confidence interval (CI) 1.887-3.660; P < 0.001). Validation data patients were divided into two groups (RPV low, n = 420) and RPV high (n = 47). Multivariate analysis revealed that risk of recurrence was significantly higher in the RPV high than the RPV low (HR 3.053; 95% CI 1.962-4.750; P < 0.001). Conclusions: RPV can identify Stage II colon cancer patients with high risk of cancer recurrence world-wide.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Surgery