Abstract
Abstract
Peripheral nerve injury is a common injury disease. Understanding of the mechanisms of periphery nerve repair and regeneration after injury is an essential prerequisite for treating related diseases. Although the biological mechanisms of peripheral nerve injury and regeneration have been studied comprehensively, the clinical treatment methods are still limited. The bottlenecks of the treatments are the shortage of donor nerves and the limited surgical precision. Apart from the knowledge regarding the fundamental characteristics and physical processes of peripheral nerve injury, numerous studies have found that Schwann cells, growth factors, and extracellular matrix are main factors affecting the repair and regeneration process of injured nerves. At present, the therapeutical methods of the disease include microsurgery, autologous nerve transplantation, allograft nerve transplantation and tissue engineering technology. Tissue engineering technology, which combines seed cells, neurotrophic factors, and scaffold materials together, is promising for treating the patients with long-gapped and large nerve damage. With the development of neuron science and technology, the treatment of peripheral nerve injury diseases will continue being improved.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference98 articles.
1. Negative regulation of myelination: relevance for development, injury, and demyelinating disease;Glia,2008
2. Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs;Front Physiol,2013
3. Iatrogenic peripheral nerve injuries;Neurol India,2019
4. Microsurgery of peripheral nerves;Hand,1973
5. Management of large peripheral nerve defects with autografting;Injury,2019
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献