Racial, Ethnic, and Socioeconomic Disparities in Glaucoma Onset and Severity in a Diverse Nationwide Cohort in the United States

Author:

Acuff Kaela12,Radha Saseendrakumar Bharanidharan12,Wu Jo-Hsuan12,Weinreb Robert N.1,Baxter Sally L.12

Affiliation:

1. Viterbi Family Department of Ophthalmology Division of Ophthalmology Informatics and Data Science, Shiley Eye Institute, University of California San Diego, La Jolla, CA

2. UCSD Health Department of Biomedical Informatics, University of California San Diego, La Jolla, CA

Abstract

Précis: Racial/ethnic minorities are diagnosed with glaucoma at younger ages, and Blacks are more likely to be diagnosed with moderate-to-severe glaucoma. In addition, we highlight a gap in the use of diagnosis codes. Purpose: The purpose of this study was to analyze patterns of diagnosis coding usage and validate epidemiologic patterns of glaucoma onset and severity among primary glaucoma patients within the National Institutes of Health All of Us database. Patients and Methods: We used International Classification of Disease diagnosis codes to build 4 cohorts of patients with mild, moderate, severe, and unspecified stage glaucoma (N=2982). Descriptive analyses were stratified by disease stage, and mean age at diagnosis was compared across racial and ethnic groups. Multivariable ordinal regression was used to examine risk factors for increasing glaucoma severity. Results: Of 2982 participants, 1714 (57%) had unspecified severity staging. Black/African Americans and other races were diagnosed with glaucoma at significantly younger ages compared with Whites (means 60 and 60 vs. 66 y; P<0.001). Hispanic/Latino participants also had an earlier mean age of diagnosis (61 vs. 65 y; P=0.001). Black/African Americans had higher odds of more severe glaucoma (odds ratio: 2.20, 95% CI, 1.62–3.30; P<0.001) than Whites when adjusting for socioeconomic characteristics. Conclusions: Black, Hispanic/Latino, and other minority participants are diagnosed with glaucoma at younger ages, and Blacks are more likely to be diagnosed with moderate-to-severe glaucoma. These findings validate prior population-based studies. Furthermore, we observed a gap in the use of diagnosis codes, as only 43% of participants had a specified severity stage in this national cohort. This may have implications for large-scale observational research concerning glaucoma severity, as electronic health records and claims databases typically lack other measures of disease progression, such as imaging and visual field data.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology

Reference34 articles.

1. Race and ethnicity differences in disease severity and visual field progression among glaucoma patients;Halawa;Am J Ophthalmol,2022

2. Racial differences in the rate of change in anterior lamina cribrosa surface depth in the African Descent and glaucoma evaluation study;Girkin;Invest Ophthalmol Vis Sci,2021

3. Racial influences in open-angle glaucoma;Wilensky;Ann Ophthalmol,1978

4. Race as a risk factor for progressive glaucomatous damage;Wilson;Ann Ophthalmol,1985

5. Glaucoma treatment outcomes in open angle glaucoma patients of African Descent;Siesky;J Glaucoma,2022

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