Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues

Author:

Ménard Vincent,Lévesque Eric,Chen Sylvia,Eap Olivier,Joy Melanie S.,Ekström Lena,Rane Anders,Guillemette Chantal

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics(clinical),Genetics,Molecular Biology,Molecular Medicine,General Pharmacology, Toxicology and Pharmaceutics

Reference23 articles.

1. Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction.;Ohno;Drug Metab Dispos,2009

2. Human UGT2B7 catalyzes morphine glucuronidation.;Coffman;Drug Metab Dispos,1997

3. Human UDP-glucuronosyltransferase 2B7.;Radominska-Pandya;Curr Drug Metab,2001

4. Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).;Knights;Br J Clin Pharmacol,2013

5. A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity.;Duguay;Clin Pharmacol Ther,2004

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