Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality-Reference-Cited by-同舟云学术

Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality

Published:2024-07-22 Issue:8 Volume:8 Page:
ISSN:2471-254X
Container-title:Hepatology Communications
language:en
Short-container-title:

Author:

Alvarado-Tapias Edilmar¹²³⁴^ORCID,Martí-Aguado David¹⁵⁶^ORCID,Gómez-Medina Concepción¹⁵^ORCID,Ferrero-Gregori Andreu²^ORCID,Szafranska Justyna⁷^ORCID,Brujats Anna²⁴^ORCID,Osuna-Gómez Rubén⁴^ORCID,Guinart-Cuadra Albert⁴,Alfaro-Cervelló Clara⁸^ORCID,Pose Elisa³⁹^ORCID,Ventura-Cots Meritxell¹³¹⁰^ORCID,Clemente Ana¹³¹¹,Fernández-Carrillo Carlos¹³¹²^ORCID,Contreras Cynthia¹³,Cabezas Joaquin¹⁴^ORCID,López-Pelayo Hugo¹⁵^ORCID,Arab JuanPablo¹⁶¹⁷¹⁸^ORCID,Argemi Josepmaria¹³¹⁹^ORCID,Bataller Ramon¹⁹^ORCID

Affiliation:

1. Division of Gastroenterology, Hepatology and Nutrition, Center for Liver Diseases, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

2. Gastroenterology and Hepatology Department, Hospital of Santa Creu and Sant Pau, Autonomus University of Barcelona, Barcelona, Spain

3. Centre for Biomedical Research in Liver and Digestive Diseases Network (CIBERehd), Madrid, Spain

4. Inflammatory Diseases, Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain

5. Digestive Disease Department, Clínic University Hospital, Biomedical Research Institute INCLIVA, Valencia, Spain

6. CIBER-BBN, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Madrid, Spain

7. Hospital Santa Creu i Sant Pau, Instituto de Reserca Sant Pau, Universidad Autónoma de Barcelona, Departamento de Anatomía Patológica, Barcelona, Spain

8. Pathology Department, Clínic University Hospital, Biomedical Research Institute INCLIVA, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain

9. Liver Unit, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

10. Liver Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institute of Research, Universitat Autònoma de Barcelona, Barcelona, Spain

11. Department of Gastroenterology and Hepatology, Hospital General Universitario Gregorio Marañón (IISGM), Madrid, Spain

12. Liver Unit, Department of Gastroenterology and Hepatology, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, Madrid, Spain

13. Department Internal medicine, Good Samaritan Hospital, Trihealth, Cincinnati, Ohio, USA

14. Department Gastroenterology and Hepatology, University Hospital Marques de Valdecilla, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Santander, Spain

15. Department Health and Addictions Research Group, IDIBAPS, Addictions Unit, Psychiatry and Psychology Service, ICN, Red de investigación de atención primaria en adicciones (RIAPad), Hospital Clinic Barcelona, Barcelona, Spain

16. Department of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada

17. Department of Epidemiology and Biostatistics, Schulich School of Medicine, Western University, London, Ontario, Canada

18. Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile

19. Departamento de hepatología, Clínica Universidad de Navarra, Universidad de Navarra, Unidad hepática, Pamplona, Spain

Abstract

Background and Aims: Alcohol use disorder has been reported in patients undergoing bariatric procedures, but the pattern of alcohol consumption has not been evaluated. We investigated the prevalence, risk factors, and impact of binge drinking (BD) at the time of surgery and during follow-up. Methods: A prospective, longitudinal study of subjects undergoing bariatric surgery was included in the LABS-2 registry between 2006 and 2009. Participants with AUDIT questionnaire at the time of surgery and a minimum of 12 months follow-up were included. BD was defined as consuming ≥5 drinks on at least 1 occasion in the previous month. Liver biopsies were obtained during bariatric procedures in not all cases. Survival analysis was performed with the adjusted Cox regression model and competing risk. Results: A total of 2257 subjects were included, with a median follow-up of 79 months. The prevalence of BD at time of surgery was 12%, and it raised up to 23% during follow-up. Patients with BD predominantly had a binge eating disorder (OR=1.35 [95% CI: 1.04–1.76]), regularly consumed fast food [OR=1.4 (95% CI: 1.07–1.85)] and used other drugs (OR=2.65 [95% CI: 1.74–4.04]). Within liver biopsies evaluation, BD showed higher hepatic iron deposits (OR=3.00 [95% CI: 1.25–7.21]). BD at the time of surgery was associated with a higher risk of BD during follow-up (OR=10.49 [95% CI: 7.86–14.00]) and long-term mortality (HR: 3.21 [95% CI: 1.67–6.18]). Specific causes of death in these patients with BD were liver disease (p=0.020), suicide (p=0.015), neoplasms (p=0.034), and respiratory (p=0.025). Conclusions: The prevalence of BD in patients undergoing bariatric surgery is high and increases the risk of postoperative liver disease, suicides, and long-term mortality.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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1. Erratum: Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality;Hepatology Communications;2024-08-19