Specific IgA, But Not IgG, in Human Milk From COVID-19-Infected Mothers Neutralizes SARS-CoV-2-Reference-Cited by-同舟云学术

Specific IgA, But Not IgG, in Human Milk From COVID-19-Infected Mothers Neutralizes SARS-CoV-2

Published:2024-02-29 Issue:6 Volume:43 Page:532-535
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Macchiaverni Patricia¹²^ORCID,Lloyd Megan¹²³,Masters Laura³,Divakara Nivedithaa¹²,Panta Kritu³,Imrie Allison³,Sánchez-García Laura⁴,Pellicer Adelina⁴,Rodriguez Juan M.⁵,Verhasselt Valerie¹²

Affiliation:

1. From theLarsson-Rosenquist Foundation Centre for Immunology and Breastfeeding, School of Medicine, University of Western Australia, Perth, Western Australia, Australia

2. Immunology and Breastfeeding team, Telethon Kids Institute, Perth, Western Australia, Australia

3. Marshall Centre, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia

4. Department of Neonatology, Biomedical Research Foundation-IDIPAZ, La Paz University Hospital, Madrid, Spain

5. Department of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.

Abstract

This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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