Urinary Tract Infection in Children and the Potential Role of Pivmecillinam as a Treatment Option

Author:

Andersen Naja Lyhne12ORCID,Antsupova Valeria3,Boel Jonas Bredtoft3,Christensen Mette Marie1,Nygaard Ulrikka24,Schmidt Lisbeth Samsø12

Affiliation:

1. From the Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark

2. Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark

3. Department of Clinical Microbiology, Copenhagen University Hospital Herlev-Gentofte, Copenhagen, Denmark

4. Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Abstract

We investigated the potential role of pivmecillinam in the treatment of urinary tract infections in children. Among 351 children (0–6 years) with urinary tract infections, 83% could be treated with pivmecillinam following urine culture. Resistance was highest in infants (0–3 months) caused by the high prevalence of Enterococcus faecalis. This result emphasizes the necessity for developing a pediatric oral form of pivmecillinam.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference9 articles.

1. Antibiotic resistance in paediatric febrile urinary tract infections.;Esposito;J Glob Antimicrob Resist,2022

2. Pivmecillinam in the treatment of childhood pyelonephritis.;Helin;J Int Med Res,1983

3. Antibiotic resistance in paediatric UTIs in Norway.;Thaulow;Tidsskr Nor Laegeforen,2021

4. Reviving the role of mecillinam against extended spectrum beta-lactamase producing enterobacterales.;Kaleem;Iran J Microbiol,2022

5. Neonatal and pediatric oral drug delivery: hopes and hurdles.;Mfoafo;Int J Pharm,2021

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