Imported Malaria in Children: A Study Over an 11-Year Period in Brussels

Abstract

Background: Malaria is a major global public health concern in endemic countries and imported childhood malaria is increasing in malaria non-endemic countries. Methods: This was a retrospective case review of all laboratory-confirmed malaria cases in children 0–16 years admitted between 2009 and 2019 in 2 large university teaching Hospitals in Brussels. Results: A total of 160 children with a median age of 6.8 years (range 5–191 months) were included. We identified 109 (68%) children living in Belgium who had acquired malaria during their visit to malaria-endemic countries to visiting friends and relatives (VFRs), 49 children (31%) visitors or newly installed migrants, and 2 Belgian tourists. Peak seasonal incidence occurred between August and September. Plasmodium falciparum was responsible for 89% of all malaria cases. Almost 80% of children living in Belgium visited a travel clinic for advice, but only one-third reported having taken the prophylaxis schedule according to the recommendations. Based on WHO criteria, 31 children (19.3%) developed severe malaria; most of the patients with severe malaria were VFR travelers and were significantly younger, had higher leukocytosis, had more thrombocytopenia, higher CRP, and lower natremia compared with patients with an uncomplicated course. All children recovered fully. Conclusions: Malaria is a significant cause of morbidity among returning travelers and newly arrived immigrants to Belgium. Most of the children had an uncomplicated disease course. Physicians should educate families about traveling to malaria-endemic areas to correct malaria preventive measures and prophylaxis.