Genetic Association between ICAM-1 Gene Variants and Susceptibility to Ischemic Cardiomyopathy

Abstract

Abstract: The current work was aimed at exploring the association between single nucleotide polymorphisms(SNPs) in the ICAM-1 gene, along with the identification of additional haplotypes and their potential role in susceptibility to ischemic cardiomyopathy(ICM). The control group underwent a Hardy-Weinberg equilibrium test. The associations of genotypes and alleles with susceptibility to ICM were then analyzed using logistic regression analysis. Subsequently odds ratios(ORs) along with 95% confidence intervals (95%CI) were calculated. Interaction analysis was conducted between these SNPs. Furthermore, linkage disequilibrium analysis and haplotype analysis were performed on SNPs that showed interactions with each other. The incidence of ICM was significantly higher among individuals carrying the T allele of rs3093032 (OR = 2.032, 95%CI = 1.275–3.241, P = 0.003) relative to those with the C allele. Additionally, CT genotype carriers had a higher susceptibility to ICM than CC genotype carriers (OR = 2.490, 95%CI = 1.445–4.29, P = 0.001). Furthermore, three SNPs (rs3093032, rs923366, rs3093030) exhibited a strong interaction with each other, while rs281437 showed no interaction with the other three SNPs. Individuals carrying the Crs3093032-Trs923366-Crs3093030haplotype had an elevated risk of ICM compared with those carrying the Crs3093032-Crs923366-Crs3093030 haplotype (OR:2.280, 95%CI:1.568–3.315, P<0.001). Moreover, individuals carrying the Trs3093032-Crs923366-Crs3093030 haplotype were more susceptible to ICM than those carrying the Crs3093032-Crs923366-Crs3093030 haplotype (OR:2.388,95%CI:1.469–3.880, P<0.001). Regarding rs3093032the minor alleles and haplotypes are associated with an increased ICM risk，three SNPs (rs3093032, rs923366, rs3093030) in ICAM-1 have strong interaction with each other.