The American Society of Transplant Surgeons Consensus Statement on Normothermic Regional Perfusion

Author:

Wall Anji E.1,Adams Bradley L.2,Brubaker Aleah3,Chang Cherylee W.J.4,Croome Kristopher P.5,Frontera Jennifer6,Gordon Elisa7,Hoffman Jordan8,Kaplan Lewis J.910,Kumar Deepali11,Levisky Josh12,Miñambres Eduardo13,Parent Brendan14,Watson Christopher15,Zemmar Ajmal16,Pomfret Elizabeth A.17

Affiliation:

1. Division of Abdominal Transplantation, Baylor Simmons Transplant Institute, Dallas, TX.

2. Southwest Transplant Alliance, Inc, Dallas, TX.

3. Department of Surgery, University of California San Diego, San Diego, CA.

4. Neurocritical Care Division, Department of Neurology, Duke University, Durham, NC.

5. Department of Surgery, Mayo Clinic, Jacksonville, FL.

6. Department of Neurology, NYU Grossman School of Medicine, New York, NY.

7. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN.

8. Heart and Lung Transplantation and CTEPH Program, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO.

9. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

10. Surgical Critical Care Section, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.

11. Transplant Infectious Diseases, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.

12. Division of Hepatology, Department of Medicine, Northwestern Medicine, Chicago, IL.

13. Donor Transplant Coordination Unit and Intensive Care Service, Hospital Universitario de Marqués de Valdecilla-IDIVAL, Spain.

14. Division of Medical Ethics, NYU Grossman School of Medicine, New York, NY.

15. Department of Surgery, University of Cambridge, Cambridge, United Kingdom.

16. Department of Neurosurgery, University of Louisville, Louisville, KY.

17. Division of Transplant Surgery and Colorado Center for Transplantation Care, Research and Education (CCTCARE), University of Colorado Anschutz Medical Campus, Denver, CO.

Abstract

On June 3, 2023, the American Society of Transplant Surgeons convened a meeting in San Diego, California to (1) develop a consensus statement with supporting data on the ethical tenets of thoracoabdominal normothermic regional perfusion (NRP) and abdominal NRP; (2) provide guidelines for the standards of practice that should govern thoracoabdominal NRP and abdominal NRP; and (3) develop and implement a central database for the collection of NRP donor and recipient data in the United States. National and international leaders in the fields of neuroscience, transplantation, critical care, NRP, Organ Procurement Organizations, transplant centers, and donor families participated. The conference was designed to focus on the controversial issues of neurological flow and function in donation after circulatory death donors during NRP and propose technical standards necessary to ensure that this procedure is performed safely and effectively. This article discusses major topics and conclusions addressed at the meeting.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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