A case of uveitis associated with novel corona-virus inactivated vaccine engineered CHO cells: A case report

Abstract

Rationale: The pathogenesis and course of recombinant Corona Virus Disease 2019 vaccine (CHO cell) associated uveitis is rarely seen in clinical practice, thus, it is difficult and time-consuming to diagnose. Patient concerns: An adult female patient suffered from binocular visual impairment after receiving the Corona Virus Disease 2019 vaccine. The patient was healthy and had no family history of retinal dystrophy previously. This case showed the following features in multimodal imaging including scattered speckled fluorescein leakage was seen around the optic disc, and the leakage was slightly enhanced in the later stage. The macular area showed about 4 papillary diameter size discoid retinal detachment area fluorescein pool staining. Optical coherence tomography showed retinal choroidal folds above the optic disc, a small amount of fluid under the neuroepithelial layer, and serous detachment of the neuroepithelial layer in the macular area. Diagnosis: Posterior uveitis of both eyes. Intervention: Orally Maizhiling, Ginkgo biloba leaves, and multivitamins. Outcome: After treatment, the symptoms of the patient were significantly improved, and optical coherence tomography reexamination showed exudation had been absorbed. Lessons: The injection of a novel coronavirus-inactivated vaccine (CHO cell) can lead to potential uveitis disorders, which is worthy of clinical attention, but the prognosis of patients is good.