Author:
Shu Qiaoqiao,He Xubing,Chen Xi,Liu Mengna,Chen Yue,Cai Liang
Abstract
Purpose
We aimed to compare the potential value of 68Ga-FAPI-04 and 18F-FDG PET/CT in primary cervical cancer and lymph node metastases.
Methods
Patients with cervical cancer underwent both 68Ga-FAPI-04 and 18F-FDG PET/CT. Histopathology and follow-up CT or MRI results (at least 3 months of follow-up) were used as reference criteria. Paired-sample t test was used to compare the SUVmax of 18F-FDG and 68Ga-FAPI-04 PET/CT for cervical cancer primary lesions and metastatic lymph nodes.
Results
A total of 35 patients with a mean age of 53 ± 11 years (range, 30–76 years) were included. The detection rate of both tracers for primary tumors was 100%. There was no significant correlation between 18F-FDG and 68Ga-FAPI-04 for SUVmax (14.5 ± 5.7 vs 15.1 ± 6.2; P = 0.645). In addition, the detection rates of 68Ga-FAPI-04 and 18F-FDG for lymph node metastasis were 100% and 98%, respectively. No significant difference was found in SUVmax between 18F-FDG and 68Ga-FAPI-04 groups (7.6 ± 4.0 vs 7.0 ± 3.5; P = 0.572). Twelve false-positive lymph nodes were detected in 8 patients with 18F-FDG PET/CT, none of which were developed on 68Ga-FAPI-04 PET/CT.
Conclusion
68Ga-FAPI-04 PET/CT has a high tracer rate for the diagnosis of primary cervical cancer and lymph node metastases. Moreover, 68Ga-FAPI-04 PET/CT also showed good results in distinguishing metastatic lymph nodes from reactive lymph nodes of cervical cancer.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Radiology, Nuclear Medicine and imaging,General Medicine
Cited by
6 articles.
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