Red Blood Cell Vitamin C Concentration and Its Effect on Deformability in Pediatric Sickle Cell Disease-Reference-Cited by-同舟云学术

Red Blood Cell Vitamin C Concentration and Its Effect on Deformability in Pediatric Sickle Cell Disease

Published:2023-02-13 Issue:7 Volume:45 Page:e936-e939
ISSN:1077-4114
Container-title:Journal of Pediatric Hematology/Oncology
language:en
Short-container-title:

Author:

Choi Daniel H.¹²^ORCID,Violet Pierre-Christian³,Majumdar Suvankar⁴,Levine Mark³

Affiliation:

1. Division of Critical Care Medicine, Department of Pediatrics, Children’s National Hospital, George Washington School of Medicine and Health Sciences

2. Division of Pediatric Critical Care Medicine, Department of Pediatrics, Hasbro Children’s Hospital, Warren Alpert Medical School of Brown University, Providence, RI

3. Molecular and Clinical Nutrition Section, Digestive Disease Branch, Intramural Research Program, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD

4. Division of Hematology, Department of Pediatrics, Children’s National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC

Abstract

Red cell rigidity is common in sickle cell disease (SCD). The contribution of oxidative stress on deformability remains unknown. This study investigated red blood cell (RBC) vitamin C concentrations in pediatric SCD (n=43) compared with healthy controls (n=23) and developed a protocol to raise RBC vitamin C concentrations to measure the effect on deformability. Sickle cell RBC vitamin C concentrations seem low (20.5 μM, SD: 16.2 vs. 51.7 μM, SD: 15.8; P<0.0001). Vitamin C can be successfully loaded into sickle cell RBCs but seems to have minimal effect on deformability. Future studies are needed to understand the clinical implications of vitamin C deficiency in pediatric SCD.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

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