Affiliation:
1. Department of Gastroesophageal Reflux Disease, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Abstract
Background:
Gastroesophageal reflux-related chronic cough (GERC), is one common type of chronic cough. Drug treatment is effective for some GERC patients. But, there is refractory GERC (rGERC). For rGERC, fundoplication may be the only effective method. However, there were very few studies about laparoscopic fundoplication in treating rGERC, and the cure rate of fundoplication in treating rGERC was unknown. So there is a question, what is the cure rate of fundoplication in treating rGERC? To solve this question, we performed this meta-analysis.
Methods:
The PRISMA strategy and Cochrane collaboration method were used for this study. Our study was registered with PROSPERO (ID: CRD42021251072). We searched PubMed, Medline, Web of Science, and the Cochrane databases from 1990 to December 2022. The meta-analysis was performed with Review Manager 5.4 and Stata 14.
Results:
After selection and exclusion, 8 articles out of 672 were included. The meta-analysis showed the cure rate of laparoscopic fundoplication in treating rGERC was 62% (95% confidence interval: 53–71%), with no deaths in 503 patients. There was no significant heterogeneity or bias in the meta-analysis.
Conclusions:
In terms of safety, laparoscopic fundoplication is quite reliable offered by skilled surgeons. In terms of cure rate, laparoscopic fundoplication could completely heal two-thirds of rGERC patients; however, there are still some patients who can not be completely cured by fundoplication.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference30 articles.
1. Gastroesophageal reflux disease (GERD): highlighting diagnosis, treatment, and lifestyle changes.;Chhabra;Cureus,2022
2. Gastro-oesophageal reflux disease.;Fass;Nat Rev Dis Primers,2021
3. Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough.;Kanemitsu;Allergol Int,2019
4. New approaches to gastroesophageal reflux disease.;Kethman;J Gastrointest Surg,2017
5. Airway hypersensitivity, reflux, and phonation contribute to chronic cough.;Francis;Clin Gastroenterol Hepatol,2016
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Non-Acid GERC: Pathogenesis, Diagnosis and Management;International Journal of Innovative Science and Research Technology (IJISRT);2024-05-13
2. Chronic cough and refractory chronic cough: An important distinction;Journal of Precision Respiratory Medicine;2023-12-01