Left atrial deformation and risk of transient ischemic attack and stroke in patients with paroxysmal atrial fibrillation

Abstract

Left atrial (LA) remodeling is closely related to the occurrence of cerebral stroke; however, the relationship between early-stage impaired deformability of the left atrium and stroke/transient ischemic attack (TIA) remains unclear. The aim of this study was to evaluate the changes in LA deformability and to assess its relationship with stroke/TIA events using speckle tracking echocardiography. A total of 365 patients with paroxysmal atrial fibrillation (non-stroke/TIA [n = 318]; stroke/TIA [n = 47]) underwent comprehensive echocardiography with speckle tracking imaging to calculate mean LA longitudinal strain and strain rate values from apical 4-chamber, 2-chamber, and 3-chamber views. The stroke/TIA group was older, had a greater proportion of males, and had lower LA strain rate during left ventricular early diastole (SRE), and the difference was statistically significant (P < .05). On univariate linear regression analysis, the following clinical and conventional echocardiographic parameters showed a significant linear correlation (P < .001) with SRE: E/A ratio; LA volume index (VI); body mass index; mean E/e′; left ventricular ejection fraction; age; and hypertension. Multiple linear regression analysis revealed a linear dependence between SRE and E/A ratio, LA VI, and body mass index. The regression equation was y = −1.430–0.394X1 + 0.012X2 + 0.019X3 (P < .001) (y, SRE; X1, E/A ratio; X2, LA VI; X3, body mass index). In multivariate logistic regression analyses, SRE and sex ratio were independent risk factors for stroke/TIA (SRE, odds ratio 2.945 [95% confidence interval 1.092–7.943]; P = .033; sex, odds ratio 0.462 [95% confidence interval 0.230–0.930]; P = .031). Among patients with paroxysmal atrial fibrillation, SRE reflected impaired deformability of the left atrium in the early stages and was associated with the risk of stroke/TIA.