Two cases of inflammatory myofibroblastic tumor treated with targeted drugs: A case report

Author:

Liu Mengyao1ORCID,Zhu Dongyuan1

Affiliation:

1. Rare Tumors Department, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Abstract

Introduction: Inflammatory myofibroblastic tumor (IMT) is a rare invasive soft tissue tumor. Many IMTs are positive for anaplastic lymphoma kinase (ALK) with ALK gene fusion; other gene mutations have also been reported, which indicates a key role for genetic testing and the development of target therapy to optimize treatment strategies. Patient concerns: We report 2 patients who obtained clinical benefits following targeted treatment with ensartinib. Diagnosis: The first patient was diagnosed as IMT, with TFG-ROS1 fusion gene mutation. The second patient was IMT harboring the ALK-STRN fusion gene mutation. Interventions: We performed gene testing for these 2 patients. According to the test result, both patients received ensartinib 225 mg QD as targeted therapy for a 30-day cycle. Outcomes: The first patient achieved partial remission and maintained a stable state for 14.7 months. The second patient was treated for 10 months and reached complete remission after 5 months and is currently still benefiting from treatment. Treatment-related side effects were mild in both patients. Conclusion: Our cases provided some new insights and approaches for the clinical diagnosis and treatment of IMT.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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