APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

Author:

Sienski Grzegorz1ORCID,Narayan Priyanka123ORCID,Bonner Julia Maeve12ORCID,Kory Nora1ORCID,Boland Sebastian4ORCID,Arczewska Aleksandra A.5,Ralvenius William T.2ORCID,Akay Leyla2ORCID,Lockshin Elana2ORCID,He Liang6,Milo Blerta2,Graziosi Agnese2ORCID,Baru Valeriya1ORCID,Lewis Caroline A.1ORCID,Kellis Manolis78ORCID,Sabatini David M.1791011ORCID,Tsai Li-Huei27ORCID,Lindquist Susan1910

Affiliation:

1. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

2. Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.

3. Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA.

4. Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

5. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

6. Duke University, Durham, NC 27708, USA.

7. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

8. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

9. Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

10. Howard Hughes Medical Institute, Cambridge, MA 02139, USA.

11. Koch Institute for Integrative Cancer Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02139, USA.

Abstract

APOE4 -disrupted intracellular lipid homeostasis in human and yeast cells was reversed by promoting phospholipid synthesis through choline supplementation.

Funder

National Institutes of Health

Howard Hughes Medical Institute

National Institute of Mental Health

National Heart, Lung, and Blood Institute

National Human Genome Research Institute

National Institute of Neurological Disorders and Stroke

NIH Office of the Director

National Cancer Institute, Cairo University

National Institute of Development Administration

Neurodegeneration Consortium

NIH Clinical Center

Damon Runyon Cancer Research Foundation

European Molecular Biology Organization

Helen Hay Whitney Foundation

Alzheimer’s Association

NIH Blueprint for Neuroscience Research

Robert A. and Renee E. Belfer Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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