Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin-Reference-Cited by-同舟云学术

Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

Published:2021-08-25 Issue:608 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Herzog Rebecca¹²^ORCID,Sacnun Juan Manuel¹²³^ORCID,González-Mateo Guadalupe⁴^ORCID,Bartosova Maria⁵,Bialas Katarzyna¹³,Wagner Anja¹²,Unterwurzacher Markus¹²,Sobieszek Isabel J.¹²,Daniel-Fischer Lisa¹²^ORCID,Rusai Krisztina²^ORCID,Pascual-Antón Lucía⁴,Kaczirek Klaus⁶,Vychytil Andreas⁷,Schmitt Claus Peter⁵,López-Cabrera Manuel⁴,Alper Seth L.⁸⁹^ORCID,Aufricht Christoph²,Kratochwill Klaus¹²^ORCID

Affiliation:

1. Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.

2. Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

3. Zytoprotec GmbH, 1090 Vienna, Austria.

4. Tissue and Organ Homeostasis, Molecular Biology Centre Severo Ochoa, CSIC-UAM, 28049 Madrid, Spain.

5. Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University of Heidelberg, 69120 Heidelberg, Germany.

6. Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.

7. Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, Austria.

8. Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

9. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Lithium added to peritoneal dialysis fluid protects mesothelial cells and attenuates peritoneal fibrosis and angiogenesis by reducing αB-crystallin.

Funder

Horizon 2020 Framework Programme

Deutsche Forschungsgemeinschaft

Marie Curie

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference98 articles.

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3. Worldwide access to treatment for end-stage kidney disease: a systematic review

4. Biocompatible Peritoneal Dialysis: The Target Is Still Way Off

5. Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis

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