Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy-Reference-Cited by-同舟云学术

Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy

Published:2020-08-12 Issue:556 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lu Xueguang¹^ORCID,Miao Lei¹,Gao Wenting¹,Chen Ziqi¹,McHugh Kevin J.¹²^ORCID,Sun Yehui¹,Tochka Zachary¹^ORCID,Tomasic Stephanie¹^ORCID,Sadtler Kaitlyn¹³^ORCID,Hyacinthe Alain¹,Huang Yuxuan¹^ORCID,Graf Tyler¹^ORCID,Hu Quanyin¹,Sarmadi Morteza¹⁴⁵^ORCID,Langer Robert¹⁵⁶⁷^ORCID,Anderson Daniel G.¹⁵⁶⁷^ORCID,Jaklenec Ana¹^ORCID

Affiliation:

1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77005, USA.

3. Section on Immuno-Engineering, National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.

4. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Microfabricated particles mimic multiple intratumoral injections of STING agonist over weeks to improve ease of use and decrease metastasis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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