Prime and target immunization protects against liver-stage malaria in mice-Reference-Cited by-同舟云学术

Prime and target immunization protects against liver-stage malaria in mice

Published:2018-09-26 Issue:460 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Gola Anita¹²^ORCID,Silman Daniel¹³^ORCID,Walters Adam A.¹,Sridhar Saranya¹³,Uderhardt Stefan²^ORCID,Salman Ahmed M.¹⁴,Halbroth Benedict R.¹,Bellamy Duncan¹^ORCID,Bowyer Georgina¹^ORCID,Powlson Jonathan¹,Baker Megan¹³,Venkatraman Navin¹³,Poulton Ian¹³^ORCID,Berrie Eleanor⁵^ORCID,Roberts Rachel¹³,Lawrie Alison M.¹³,Angus Brian⁶^ORCID,Khan Shahid M.⁴^ORCID,Janse Chris J.⁴,Ewer Katie J.¹^ORCID,Germain Ronald N.²^ORCID,Spencer Alexandra J.¹,Hill Adrian V. S.¹

Affiliation:

1. Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

2. Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.

4. Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

5. Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford OX3 7JT, UK.

6. Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Abstract

A prime and target vaccine for liver-stage malaria results in sterile protection in mouse disease models and appears safe for human use.

Funder

Wellcome Trust

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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