Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage-Reference-Cited by-同舟云学术

Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

Published:2016-07-06 Issue:346 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Heinemeier Katja M.¹²,Schjerling Peter¹,Heinemeier Jan³,Møller Mathias B.¹,Krogsgaard Michael R.⁴,Grum-Schwensen Tomas⁵,Petersen Michael M.⁵,Kjaer Michael¹

Affiliation:

1. Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2400 Copenhagen NV, Denmark.

2. Department of Biomedical Sciences, Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

3. AMS 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C, Denmark.

4. Section for Sports Traumatology M51, Department of Orthopaedic Surgery M, Bispebjerg-Frederiksberg Hospital, 2400 Copenhagen NV, Denmark.

5. Musculoskeletal Tumor Section, Department of Orthopaedic Surgery, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen O, Denmark.

Abstract

The turnover of cartilage collagen matrix is minimal in human adults and is not influenced by disease.

Funder

Danish Medical Research Council

Danish Rheumatism Association

Lundbeck Foundation

Novo Nordisk Foundation

Nordea Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine