Distilling complexity to advance cardiac tissue engineering

Author:

Ogle Brenda M.1,Bursac Nenad2,Domian Ibrahim3,Huang Ngan F.45,Menasché Philippe6,Murry Charles E.7,Pruitt Beth8,Radisic Milica9,Wu Joseph C.10,Wu Sean M.11,Zhang Jianyi12,Zimmermann Wolfram-Hubertus13,Vunjak-Novakovic Gordana14

Affiliation:

1. Department of Biomedical Engineering, Stem Cell Institute, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

2. Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

3. Harvard Medical School and Harvard Stem Cell Institute, Boston, MA 02114, USA.

4. Department of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.

5. Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.

6. Department of Cardiovascular Surgery, INSERM U 970, Hôpital Européen Georges Pompidou and University Paris Descartes, 75006 Paris, France.

7. Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, Departments of Pathology, Bioengineering, and Medicine, University of Washington, Seattle, WA 98109, USA.

8. Departments of Mechanical Engineering and, by courtesy, Molecular and Cellular Physiology and Bioengineering, Stanford University, Stanford, CA 94305, USA.

9. Institute of Biomaterials and Biomedical Engineering, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

10. Stanford Cardiovascular Institute and Departments of Medicine and Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

11. Departments of Medicine and Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

12. Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

13. Institute of Pharmacology and Toxicology, University Medical Center, Georg-August University Göttingen and DZHK (German Center for Cardiovascular Research), partner site Göttingen, 37075 Göttingen, Germany.

14. Departments of Biomedical Engineering and Medicine, Columbia University, New York, NY 10032, USA.

Abstract

Five central challenges must be met to advance the current state of the art in modeling heart disease and realizing heart repair.

Funder

NIH Progenitor Cell Biology Consortium

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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