A cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough-Reference-Cited by-同舟云学术

A cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough

Published:2015-12-02 Issue:316 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Nguyen Annalee W.¹,Wagner Ellen K.¹,Laber Joshua R.¹,Goodfield Laura L.²,Smallridge William E.²,Harvill Eric T.²,Papin James F.³,Wolf Roman F.³,Padlan Eduardo A.⁴,Bristol Andy⁵,Kaleko Michael⁵,Maynard Jennifer A.¹

Affiliation:

1. Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

2. Department of Veterinary and Biomedical Science, Pennsylvania State University, University Park, PA 16802, USA.

3. Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

4. The Marine Science Institute, College of Science, University of the Philippines Diliman, Quezon City 1101, Philippines.

5. Synthetic Biologics, 155 Gibbs Street, Suite 412, Rockville, MD 20850, USA.

Abstract

A humanized antibody cocktail alleviates the high white blood cell count associated with severe pertussis infection and increases bacterial clearance in murine and baboon models.

Funder

NIH

Welch F-1767

Norman Hackerman Advanced Research Project

Synthetic Biologics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference41 articles.

1. Pertussis: Challenges Today and for the Future

2. Global, regional, and national causes of child mortality in 2008: a systematic analysis