The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

Author:

Mlecnik Bernhard123,Bindea Gabriela123,Kirilovsky Amos123,Angell Helen K.1234,Obenauf Anna C.5,Tosolini Marie123,Church Sarah E.123,Maby Pauline123,Vasaturo Angela123,Angelova Mihaela123,Fredriksen Tessa123,Mauger Stéphanie123,Waldner Maximilian6,Berger Anne7,Speicher Michael R.5,Pagès Franck1238,Valge-Archer Viia9,Galon Jérôme123

Affiliation:

1. INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France.

2. Université Paris Descartes, Sorbonne Paris Cité, UMRS1138, F-75006 Paris, France.

3. Sorbonne Universités, UPMC Univ Paris 06, UMRS1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.

4. AstraZeneca, Cambridge CB4 OWG, UK.

5. Institute of Human Genetics, Medical University of Graz, Graz, Austria.

6. Department of Medicine, University of Erlangen-Nuremberg, Erlangen, Germany.

7. Assistance Publique–Hopitaux de Paris, Department of General and Digestive Surgery, Hôpital Européen Georges Pompidou, Paris, France.

8. Assistance Publique–Hopitaux de Paris, Department of Immunology, Hôpital Européen Georges Pompidou, Paris, France.

9. MedImmune Ltd., Cambridge CB21 GGH, UK.

Abstract

Local lymphatic vessel density and immune cytotoxicity prevent metastatic invasion.

Funder

National Cancer Institute of France (INCa)

Canceropole Ile de France

Ville de Paris

MedImmune

INSERM

Geninca Consortium

Cancer Research for Personalized Medicine (CARPEM)

European Commission

Paris Alliance of Cancer Research Institutes (PACRI)

LabEx Immuno-oncology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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