Genomic profiling of ER + breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance-Reference-Cited by-同舟云学术

Genomic profiling of ER + breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance

Published:2017-08-09 Issue:402 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Giltnane Jennifer M.¹²^ORCID,Hutchinson Katherine E.³^ORCID,Stricker Thomas P.¹²^ORCID,Formisano Luigi³,Young Christian D.³,Estrada Monica V.²^ORCID,Nixon Mellissa J.⁴^ORCID,Du Liping⁵^ORCID,Sanchez Violeta²^ORCID,Ericsson Paula Gonzalez²^ORCID,Kuba Maria G.¹^ORCID,Sanders Melinda E.¹²^ORCID,Mu Xinmeng J.⁶^ORCID,Van Allen Eliezer M.⁶⁷^ORCID,Wagle Nikhil⁶⁷,Mayer Ingrid A.²³^ORCID,Abramson Vandana²³,Gόmez Henry⁸,Rizzo Monica⁹,Toy Weiyi¹⁰^ORCID,Chandarlapaty Sarat¹⁰^ORCID,Mayer Erica L.⁷^ORCID,Christiansen Jason¹¹^ORCID,Murphy Danielle¹¹^ORCID,Fitzgerald Kerry¹¹^ORCID,Wang Kai¹²,Ross Jeffrey S.¹²¹³^ORCID,Miller Vincent A.¹²,Stephens Phillip J.¹²,Yelensky Roman¹²,Garraway Levi⁶⁷¹⁴,Shyr Yu⁵^ORCID,Meszoely Ingrid²¹⁵,Balko Justin M.²³⁴,Arteaga Carlos L.²³⁴^ORCID

Affiliation:

1. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

2. Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

3. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

4. Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

5. Vanderbilt Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

6. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

7. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

8. Instituto Nacional de Enfermedades Neoplásicas, Surquillo 15038, Peru.

9. Department of Surgery, Emory University, Atlanta, GA 30322, USA.

10. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA.

11. Genoptix Medical Laboratories, Carlsbad, CA 92008, USA.

12. Foundation Medicine Inc., Cambridge, MA 02141, USA.

13. Department of Pathology, Albany Medical College, Albany, NY 12208, USA.

14. Joint Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

15. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

Genomic profiling of ER + /HER2 − breast tumors after short-term estrogen deprivation revealed alterations associated with intrinsic resistance and provided mechanistic insights.

Funder

National Institutes of Health

U.S. Department of Defense

National Cancer Institute

Susan G. Komen

Breast Cancer Research Foundation

Novartis

Vanderbilt Institute for Clinical and Translational Research

Vanderbilt-Ingram Cancer Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject