RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis-Reference-Cited by-同舟云学术

RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis

Published:2017-01-25 Issue:374 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Andrade Kelsi¹,Fornetti Jaime¹,Zhao Ling¹,Miller Scott C.²,Randall R. Lor³,Anderson Neysi¹,Waltz Susan E.⁴,McHale Mark⁵,Welm Alana L.¹

Affiliation:

1. Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

2. Department of Radiology and Imaging Sciences, Division of Radiobiology, University of Utah, Salt Lake City, UT 84112, USA.

3. Department of Orthopaedics, University of Utah, Salt Lake City, UT 84112, USA.

4. Department of Cancer and Cell Biology, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45267, USA.

5. Aslan Pharmaceuticals, Singapore 089824, Singapore.

Abstract

Inhibition of RON kinase prevents pathogenic bone destruction in mouse models and in a first-in-human clinical study.

Funder

U.S. Department of Defense Breast Cancer Research Program

Susan G. Komen Postdoctoral Fellowship

National Cancer Institute

Oklahoma Medical Research Foundation

Stephenson Cancer Center at the University of Oklahoma

Huntsman Cancer Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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