Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice-Reference-Cited by-同舟云学术

Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice

Published:2021-03-10 Issue:584 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Moreno Ana M.¹^ORCID,Alemán Fernando¹^ORCID,Catroli Glaucilene F.²^ORCID,Hunt Matthew²^ORCID,Hu Michael¹^ORCID,Dailamy Amir¹^ORCID,Pla Andrew¹,Woller Sarah A.²^ORCID,Palmer Nathan³^ORCID,Parekh Udit⁴^ORCID,McDonald Daniella¹⁵,Roberts Amanda J.⁶^ORCID,Goodwill Vanessa⁷,Dryden Ian⁷^ORCID,Hevner Robert F.⁷^ORCID,Delay Lauriane²^ORCID,Gonçalves dos Santos Gilson²^ORCID,Yaksh Tony L.²^ORCID,Mali Prashant¹^ORCID

Affiliation:

1. Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

2. Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.

3. Division of Biological Sciences, University of California San Diego , San Diego, CA 92093, USA.

4. Department of Electrical Engineering, University of California San Diego , San Diego, CA 92093, USA.

5. Biomedical Sciences Graduate Program, University of California San Diego, San Diego, San Diego, CA 92093, USA.

6. Animal Models Core, Scripps Research Institute, La Jolla, CA 92037, USA.

7. Department of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.

Abstract

In situ genome targeting of Na V 1.7 via CRISPRs and zinc fingers enables genomically scarless, durable, and nonaddictive management of pain.

Funder

National Institutes of Health

São Paulo Research Foundation

NIH-NINDS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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