β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade-Reference-Cited by-同舟云学术

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

Published:2020-01-15 Issue:526 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Fang¹^ORCID,Gannon Mary¹^ORCID,Chen Yunjia¹,Yan Shun²^ORCID,Zhang Sixue³^ORCID,Feng Wendy¹^ORCID,Tao Jiahui¹^ORCID,Sha Bingdong¹^ORCID,Liu Zhenghui⁴,Saito Takashi⁵^ORCID,Saido Takaomi⁵^ORCID,Keene C. Dirk⁶^ORCID,Jiao Kai²^ORCID,Roberson Erik D.⁷^ORCID,Xu Huaxi⁸,Wang Qin¹^ORCID

Affiliation:

1. Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

2. Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

3. Department of Chemistry, Southern Research Institute, Birmingham, AL 35205, USA.

4. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5. Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198, Japan.

6. Department of Pathology, University of Washington, Seattle, WA 98104, USA.

7. Alzheimer’s Disease Center, Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

8. Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

Abstract

Noradrenergic signaling sensitizes pathological GSK3β/tau activation to nanomolar Aβ.

Funder

National Institute of Mental Health

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.