Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development-Reference-Cited by-同舟云学术

Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development

Published:2020-07-08 Issue:551 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Nakamura Yuumi¹²^ORCID,Takahashi Hiroki³⁴^ORCID,Takaya Akiko⁵^ORCID,Inoue Yuzaburo⁶^ORCID,Katayama Yuki¹^ORCID,Kusuya Yoko³^ORCID,Shoji Tatsuma⁵^ORCID,Takada Sanami¹,Nakagawa Seitaro¹^ORCID,Oguma Rena¹^ORCID,Saito Nobuko¹,Ozawa Naoko⁶^ORCID,Nakano Taiji⁶^ORCID,Yamaide Fumiya⁶^ORCID,Dissanayake Eishika⁶^ORCID,Suzuki Shuichi⁷^ORCID,Villaruz Amer⁸,Varadarajan Saranyaraajan⁹^ORCID,Matsumoto Masanori⁹^ORCID,Kobayashi Tomoko¹⁰,Kono Michihiro¹⁰,Sato Yasunori¹¹,Akiyama Masashi¹⁰^ORCID,Otto Michael⁸^ORCID,Matsue Hiroyuki¹³^ORCID,Núñez Gabriel⁹^ORCID,Shimojo Naoki⁶

Affiliation:

1. Department of Dermatology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.

2. Cutaneous Immunology, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

3. Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan.

4. Molecular Chirality Research Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

5. Laboratory of Microbiology and Immunology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.

6. Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.

7. Department of Pediatrics, Shimoshizu National Hospital, Chiba 284-0003, Japan.

8. Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

9. Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

10. Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi 466-8550, Japan.

11. Department of Global Clinical Research, Chiba University Graduate School of Medicine, Chiba 260-0870, Japan.

Abstract

Skin colonization at 6 months of age by S. aureus with functional Agr quorum sensing associates with later atopic dermatitis development in infants.

Funder

JSPS

AMED-CREST

MEXT

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

1. Epidermal barrier formation and recovery in skin disorders

2. Staphylococcus aureusInfections

3. Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting

4. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

5. Regulation of virulence determinants inStaphylococcus aureus: complexity and applications

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