Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps-Reference-Cited by-同舟云学术

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

Published:2016-10-19 Issue:361 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Park Juwon¹,Wysocki Robert W.¹²³,Amoozgar Zohreh⁴,Maiorino Laura¹⁵,Fein Miriam R.¹³,Jorns Julie⁶,Schott Anne F.⁶,Kinugasa-Katayama Yumi¹,Lee Youngseok⁷,Won Nam Hee⁷,Nakasone Elizabeth S.¹⁵,Hearn Stephen A.⁸,Küttner Victoria¹,Qiu Jing¹,Almeida Ana S.¹,Perurena Naiara¹,Kessenbrock Kai⁹,Goldberg Michael S.⁴¹⁰,Egeblad Mikala¹

Affiliation:

1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

2. Medical Scientist Training Program, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

3. Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794, USA.

4. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

5. Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA.

6. University of Michigan, Ann Arbor, MI 48109, USA.

7. Department of Pathology, Korea University Anam Hospital, Seoul, South Korea.

8. Cold Spring Harbor Laboratory Cancer Center, NCI Shared Resources and St. Giles Foundation Advanced Microscopy Center, Cold Spring Harbor, NY 11724, USA.

9. University of California, Irvine, Irvine, CA 92697, USA.

10. Department of Microbiology and Immunobiology at Harvard Medical School, Boston, MA 02115, USA.

Abstract

Treatment with DNase I–coated nanoparticles prevents metastasis by targeting neutrophil extracellular traps induced by cancer cells in a mouse model.

Funder

CSHL Cancer Center Support

U.S. Department of Defense

Long Island 2-Day Walk to Fight Breast Cancer

Joni Gladowsky Breast Cancer Foundation

NIH

Hope Foundation

Cancer Research Institute