Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age

Author:

Emerson Robert W.1ORCID,Adams Chloe2,Nishino Tomoyuki2,Hazlett Heather Cody13ORCID,Wolff Jason J.4ORCID,Zwaigenbaum Lonnie5,Constantino John N.2ORCID,Shen Mark D.1ORCID,Swanson Meghan R.1ORCID,Elison Jed T.6ORCID,Kandala Sridhar2ORCID,Estes Annette M.7ORCID,Botteron Kelly N.28ORCID,Collins Louis9ORCID,Dager Stephen R.1011ORCID,Evans Alan C.9ORCID,Gerig Guido12ORCID,Gu Hongbin1ORCID,McKinstry Robert C.8,Paterson Sarah13,Schultz Robert T.13ORCID,Styner Martin1ORCID,Schlaggar Bradley L.2814ORCID,Pruett John R.2,Piven Joseph13,

Affiliation:

1. Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC 27510, USA.

2. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.

4. Department of Educational Psychology, University of Minnesota, Minneapolis, MN 55455, USA.

5. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

6. Institute of Child Development, University of Minnesota, Minneapolis, MN 55455, USA.

7. Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98105, USA.

8. Mallinckrodt Institute of Radiology, Washington University, Washington University School of Medicine, St. Louis, MO 63110, USA.

9. Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

10. Center on Human Development and Disability, University of Washington, Seattle, WA 98105, USA.

11. Department of Radiology, University of Washington, Seattle, WA 98105, USA.

12. Tandon School of Engineering, New York University, Brooklyn, NY 11201, USA.

13. Center for Autism Research, Department of Pediatrics, Children’s Hospital of Philadelphia, and University of Pennsylvania, Philadelphia, PA 19104, USA.

14. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Functional brain imaging of 6-month-old infants with a high familial risk for autism predicts a diagnosis of autism at 24 months of age.

Funder

National Institute of Child Health and Human Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference57 articles.

1. American Psychiatric Association Ed. Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association ed. 5 2013).

2. Developmental Disabilities Monitoring Network Surveillance Year and 2010 Principal Investigators Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network (Morbidity and Mortality Weekly Report Surveillance Summaries 2002).

3. The Lifetime Distribution of the Incremental Societal Costs of Autism

4. Costs of Autism Spectrum Disorders in the United Kingdom and the United States

5. The motivation for very early intervention for infants at high risk for autism spectrum disorders

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