Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury-Reference-Cited by-同舟云学术

Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury

Published:2016-12-14 Issue:369 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Suárez-Calvet Marc¹²,Araque Caballero Miguel Ángel³,Kleinberger Gernot²⁴,Bateman Randall J.⁵⁶⁷,Fagan Anne M.⁵⁶⁷,Morris John C.⁵⁶⁷,Levin Johannes¹⁸,Danek Adrian¹⁸,Ewers Michael³,Haass Christian¹²⁴,

Affiliation:

1. German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.

2. Biomedical Center, Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

3. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.

4. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

5. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Knight Alzheimer’s Disease Research Center, Washington University in St. Louis, St. Louis, MO 63110, USA.

7. Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO 63110, USA.

8. Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.

Abstract

CSF sTREM2 increases in early stages of autosomal dominant Alzheimer’s disease, but the increase occurs after changes in Aβ and tau.

Funder

European Research Council

European Union’s Seventh Framework Program

Deutsche Forschungsgemeinschaft

ERC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference68 articles.

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4. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

5. The amyloid hypothesis of Alzheimer's disease at 25 years

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